Search results for "Liver immunology"

Liver Perfusate Natural Killer Cells from Deceased Brain Donors and Association with Acute Cellular Rejection after Liver Transplantation: A Time-to-…

2019

Background The ability to predict which recipients will successfully complete their posttransplant clinical course, which is crucial for liver transplant (LT) programs. The assessment of natural killer (NK) cell subset determined by flow cytometry from a monocentric series of consecutive liver perfusates could help identify risk factors portending adverse LT outcomes. Methods Liver perfusates were collected during the back-table surgical time after the procurement procedures for donors after brain death. Lymphocytic concentrations and phenotypes were matched with donors after brain death characteristics and indications, timing, surgical techniques, outcomes, and biopsy-proven acute cellular…

Th17 cells regulate liver fibrosis by targeting multiple cell types: many birds with one stone.

2012

HIV/HCV co-infection: putting the pieces of the puzzle together

2003

The most relevant consequence of human immunodeficiency virus (HIV) infection is the exposure of the patient to opportunistic agents. In addition, HIV may also modify the natural history of some non-opportunistic pathogens, which in turn may alter the course of HIV infection.

Neutrophil extracellular traps mediate bacterial liver damage

2015

Neutrophil extracellular traps (NETs) composed of DNA decorated with histones and proteases trap and kill bacteria but also injure host tissue. Here we show that during a bloodstream infection with methicillin-resistant Staphylococcus aureus, the majority of bacteria are sequestered immediately by hepatic Kupffer cells, resulting in transient increases in liver enzymes, focal ischaemic areas and a robust neutrophil infiltration into the liver. The neutrophils release NETs into the liver vasculature, which remain anchored to the vascular wall via von Willebrand factor and reveal significant neutrophil elastase (NE) proteolytic activity. Importantly, DNase although very effective at DNA remov…

Cellul�re Immunreaktionen gegen�ber homologen leberspezifischen Antigenen (HLP) bei chronischen Leberentz�ndungen

1974

Es wird eine Zweiphasentechnik des Leukocyten-Migrations-Inhibitionstestes beschrieben und zum Nachweis einer cellularen Immunreaktion gegenuber Leberantigenen bei chronisch-entzundlichen Lebererkrankungen eingesetzt. Mit dieser Technik wurde bei 85% der Patienten mit hypergammaglobulinamischer Verlaufsform einer chronisch-aktiven Hepatitis und 42% der Patienten mit aktiv fortschreitenden kryptogenen Lebercirrhosen eine Migrationshemmung nachgewiesen. Lebergesunde Kontrollen zeigten keine, Patienten mit dem Zustand nach Hepatitis und chronisch-persistierender Hepatitis selten eine Leukocytenmigrationsinhibition gegenuber leberspezifischen Antigenen. 17% der Patienten mit chronisch-aktiver H…